The protein-protein interaction-based QTL or piQTL project aims to understand how genetic variations across of a population of yeast inbreds could potentially influence the quantitative variation of the protein-protein complex formation.
Click on Add LD blocks, CUT, SUT and XUT annotations for loading the non-coding RNA annotations. Features are seen at the chromosome level.
Choose your PPI of interest and your drug of interest from the choice boxes.
Click on Add piQTL track (DRUG & MTX +) and Add piQTL track (noDRUG & MTX +) to load the piQTLs tracks from the PPI of interest and the drug of interest that you selected in 2.
Write a gene name or its associated coordinates (Chr:Start-End) and click on the Search button to automatically zoom on that particular region of interest. At the chromosome level, clicking on a SNP will provide information on that SNP (ID, chromosome position, statistic values from the association test -effect size, standard error, p-value) Moreover, it is also providing the genome type location and if applicable, the name of that genomic feature.
Note¹: Repeating step 2 with other PPIs with or without other drug conditions will load the additional piQTL tracks in the browser.
Note²: Several options are available by clicking on the gear icon (modification of display option or deletion of track).
The graphs are interactive.